Bottle: 1000 mg x 100 Tablets
Manufacture: Deep Blue Health
Description: NZpurehealth Bovine Colostrum is made from the milk of New Zealand pasture raised dairy cows, which is produced within the first 48 hours after giving birth. It may enhance the immune system and the overall health wellbeing. It is easily absorbed by the human body and may promote bone development.
Price: NZD$153.50
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Ingredients: Natural New Zealand Colostrum powder 225mg (equivalent to 45mg IgG Immunoglobulins); 302mg whole milk powder and other tableting aids.
Dosage: Take two (2) or three (3) tablets daily as a dietary food supplement or as professionally advised.
Caution:

What is Bovine Colostrum?

Colostrum is the pre-milk fluid produced from the mother's mammary glands during the first few days after giving birth. Bovine colostrum is derived from cows. Colostrum is a rich source of antibodies, growth factors and nutrients for the suckling neonate and may provide passive immunity to the newborn against various infectious microorganisms, particularly those that affect the gastrointestinal tract. It may also have other health benefits.

The protein content of bovine colostrum is three to four times higher up to 150 grams per litre compared to 30 to 40 grams per litre than it is in regular cow's milk.

The greater part of this protein is comprised of whey proteins. Immunoglobulins, mainly IgG, make up about 75% of the whey proteins. Other substances found in bovine colostrum include casein, lactoferrin, alpha-lactalbumin, beta-lactoglobulin, and the growth factors insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGFbeta) and epidermal growth factor (EGF). In addition, bovine colostrum contains vitamins, minerals, lipids and lactose. Bovine colostrum may also contain colostrinin, also known as proline-rich polypeptide (PRP), a substance found in ovine colostrum.Bovine colostrum prepared by microfiltration is mainly composed of whey proteins and their associated immunoglobulins and the growth factors IGF-1, IGF-2, TGFbeta and EGF.

Substances such as lactose, fats, casein and lactalbumin are significantly reduced in microfiltered bovine colostrum. Hyperimmune bovine colostrum is rich in immunoglobulins of the IgG type, which are protective against such infectious microorganisms as Cryptosporidium parvum (a major cause of AIDS-associated diarrhea), diarrheogenic Escherichia coli strains, Shigella flexneri, Clostridium difficile, and rotavirus, the most common cause of severe diarrhea in young children.

Hyperimmune bovine colostrum is prepared from cows previously immunized with specific antigens. Hyperimmune bovine colostrum IgG concentrate is an orphan drug for the treatment of diarrhea in AIDS patients caused by infection with Cryptosporidium parvum.

How Does It Work?

Colostrum is highly beneficial in the unique manner in which it provides the body with its numerous immune factors. Most infectious disease-causing organisms enter the body through the mucous membranes of the intestinal tract. In order to remain healthy, it is critical that we are able to combat disease-causing organisms: bacteria, viruses, pollutants, contaminants and allergens where they attack us. Clinical research by Dr. David Tyrell, in England, in 1980, revealed that a high percentage of the antibodies and immunoglobulins present in colostrum are believed not to be absorbed but remain in the intestinal tract where they attack disease causing organisms before they penetrate the body and cause disease. The remainder are believed to be absorbed and distributed to assist in our internal defense processes. It is this combination of action that is believed to make colostrum so unique and effective as an oral supplement.

Mechanism Of Action

Hyperimmune bovine colostrum may have antimicrobial activity based on the ability of specific immunoglobulins of the IgG type to react with bacterial, viral and other microbiological antigens in the gut. Bovine colostrum contains a few immunostimulatory substances, including lactoferrin. It may also contain colostrinin or proline-rich polypeptide (PRP), another possible immunomodulatory substance. The combination of specific, as well as nonspecific, IgGs and such immunomodulatory factors as lactoferrin and PRP may afford general antimicrobial protection of the gastrointestinal tract.

Pharmacokinetics

The pharmacokinetics of bovine colostrum, particularly with regard to the immunoglobulins, is unclear. It would be expected that immunoglobulins found in bovine colostrum would be rapidly inactivated by stomach acid and proteolytic action in the small intestine. Enteric coating would protect the proteins from acid in the stomach but not from proteolytic activity in the small intestine. However, following ingestion of bovine colostrum, some immunoglobulins are found to be excreted intact in the feces after a few days. This suggests that some immunoglobulins may be more resistant to degradation in the gut.

Growth factors and other peptides and proteins in bovine colostrum are most likely degraded by proteolytic enzymes and absorbed, distributed and metabolized in the same fashion as similar dietary substances.